Dr. Gesham Magombedze 4/29/2013

Mathematical modeling of host-pathogen immunological interactions and
molecular biological systems

Dr. Gesham Magombedze

Date: 4/29/2013
Time: 3:30PM-4:30PM,
Place: 315 Armstrong Hall
*Refreshments served at 3:00p in Armstrong Hall, Room 310

Abstract: Mycobacterial infections, such as Mycobacterium avium subspecies paratuberculosis which causes Johne's disease in cattle and other ruminants and Mycobacterium tuberculosis, which is the etiological agent of tuberculosis in humans, are characterized by a persistent and slow infection progression, that can be rapid under certain conditions. Mycobacterial pathogens have the ability to adapt to the changing intracellular environment in response to a dynamic immune response. The underlying mechanisms of how the bacteria can persist despite of the host mounting a robust immune response are not clearly understood. In this talk I will illustrate how mathematical models can be used to: (i) address questions arising from biological systems and (ii) provide insights in understanding some of the bacterial mechanisms associated with its persistence using a mathematical framework that integrates gene expression data and biochemical systems theory. I will present a mathematical immunological model that describes the cattle immune response mechanisms associated with mycobacterial infection progression.

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